Uncarinic acid E
Product Specifications
CAS Number
277751-61-8
Target
Caspase|||Bcl-2 Family|||Antifection|||MEK|||PI3K|||p53
Related Pathways
PI3K/Akt/mTOR signaling|||Microbiology/Virology|||MAPK|||Proteases/Proteasome|||Apoptosis
Bioactivity
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p- (E) -coumaroyloxyursolic acid exhibits antiplasmodial activity, with the IC50 value of 2.9 microg/ml.
Smiles
CC1(C)CC[C@@]2(CC[C@]3(COC(=O)\C=C\c4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Molecular Formula
C39H54O6
Molecular Weight
618.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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