Sprengerinin C
Product Specifications
CAS Number
88861-91-0
Target
MTOR|||VEGFR|||Akt|||p38 MAPK|||NADPH-oxidase|||ROS|||PI3K|||p53
Related Pathways
Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||PI3K/Akt/mTOR signaling|||MAPK|||Apoptosis|||Immunology/Inflammation
Bioactivity
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways, two major pathways for tumor angiogenesis.
Smiles
C[C@H]1C2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O[C@]11CC[C@@H](C)CO1
Molecular Formula
C44H70O16
Molecular Weight
855.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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