(-) -Praeruptorin A
Product Specifications
CAS Number
14017-71-1
Target
ATPase, Calcium Channel, IL Receptor, P-gp
Related Pathways
Membrane transporter/Ion channel, Neuroscience, Immunology/Inflammation, Metabolism
Bioactivity
(-) -Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis; it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-) -Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
Smiles
C\C=C(\C)C(=O)O[C@@H]1[C@H](OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
Molecular Formula
C21H22O7
Molecular Weight
386.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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