2'-Deoxyguanosine 5'-monophosphate (disodium hydrate)

2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) [1][2].

Product Specifications

CAS Number

[146877-98-7]

Product Name Alternative

5'-Deoxyguanylic acid (disodium hydrate)

UNSPSC

12352211

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-deoxyguanosine-5-monophosphate-disodium-hydrate.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O[C@H]1C[C@H](N2C=NC3=C2NC(N)=NC3=O)O[C@@H]1COP(O[Na])(O[Na])=O.[x].O

Molecular Formula

C10H14N5O7P.xH2O.2Na

References & Citations

[1]Petroselli G, Dántola M L, Cabrerizo F M, et al. Oxidation of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate Photoinduced by Pterin: Type I versus Type II Mechanism[J]. Journal of the American Chemical Society, 2008, 130 (10) : 3001-3011.|[2]Song B, Sigel H. Metal Ion-Coordinating Properties of 2 ‘-Deoxyguanosine 5 ‘-Monophosphate (dGMP2-) 1 in Aqueous Solution. Quantification of Macrochelate Formation[J]. Inorganic Chemistry, 1998, 37 (8) : 2066-2069.