Neogrifolin
Product Specifications
CAS Number
23665-96-5
Target
Akt, Caspase, PARP, Ras, GSK-3
Related Pathways
Stem Cells, Apoptosis, GPCR/G Protein, Proteases/Proteasome, Chromatin/Epigenetic, Cytoskeletal Signaling, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, MAPK
Bioactivity
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg/mL, respectively.
Smiles
CC(C)=CCC\C(C)=C\CC\C(C)=C\Cc1c(C)cc(O)cc1O
Molecular Formula
C22H32O2
Molecular Weight
328.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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