Neoechinulin A
Product Specifications
CAS Number
51551-29-2
Target
NF-κB, Apoptosis, p38 MAPK, ASK, NADPH-oxidase, IκB/IKK, NOS, Beta Amyloid, COX, Prostaglandin Receptor, TNF
Related Pathways
NF-κB, Apoptosis, GPCR/G Protein, Neuroscience, MAPK, Immunology/Inflammation
Bioactivity
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎoB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-ÎoB (NF-ÎoB) p65 and p50 subunits, it has a potential to be developed as a modulator of neuroinflammatory process in Alzheimer's disease. Neoechinulin A may ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
Smiles
C[C@@H]1NC(=O)\C(NC1=O)=C\c1c([nH]c2ccccc12)C(C)(C)C=C
Molecular Formula
C19H21N3O2
Molecular Weight
323.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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