Manassantin B
Product Specifications
CAS Number
88497-88-5
Target
TNF, STAT, JNK, ERK, Antifection, NF-κB, Bcl-2 Family, p38 MAPK
Related Pathways
Apoptosis, NF-κB, Microbiology/Virology, MAPK, JAK/STAT signaling, Stem Cells
Bioactivity
Manassantin B is a potent inhibitor of NF-ÎoB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎoB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.
Smiles
C[C@H]1[C@](O[C@@]([C@@H]1C)(C2=CC(OC)=C(O[C@@H]([C@H](O)C=3C=C4C(=CC3)OCO4)C)C=C2)[H])(C5=CC(OC)=C(O[C@@H]([C@H](O)C6=CC(OC)=C(OC)C=C6)C)C=C5)[H]
Molecular Formula
C41H48O11
Molecular Weight
716.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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