Manassantin A
Product Specifications
CAS Number
88497-87-4
Target
TNF|||HIF|||NF-?B|||cAMP|||JNK|||MAPK|||COX|||STAT|||ERK|||Prostaglandin Receptor
Related Pathways
NF-?B|||Immunology/Inflammation|||Apoptosis|||Stem Cells|||GPCR/G Protein|||Neuroscience|||MAPK|||JAK/STAT signaling|||Chromatin/Epigenetic|||Angiogenesis
Bioactivity
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.
Smiles
[H][C@@]1(O[C@@]([H])([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1
Molecular Formula
C42H52O11
Molecular Weight
732.87
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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