UBP316

UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a Kb value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist[1].

Product Specifications

CAS Number

[936095-50-0]

Product Name Alternative

ACET

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ubp316.html

Purity

99.95

Solubility

1M NaOH : 80 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C(SC(C1=CC=CC=C1)=C2)=C2CN3C(N(C=C(C)C3=O)C[C@H](N)C(O)=O)=O)=O

Molecular Formula

C20H19N3O6S

Molecular Weight

429.45

References & Citations

[1]Sheila L Dargan, et al. ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 2009 Jan;56 (1) :121-30.