Kobophenol A

Product Specifications

CAS Number

124027-58-3

Target

PKC|||ROS|||DNA/RNA Synthesis|||p38 MAPK|||Bcl-2 Family|||NF-?B|||MMP|||SARS-CoV|||JNK|||CDK

Related Pathways

Cell Cycle/Checkpoint|||Microbiology/Virology|||Cytoskeletal Signaling|||MAPK|||Apoptosis|||Proteases/Proteasome|||Chromatin/Epigenetic|||NF-?B|||Immunology/Inflammation|||DNA Damage/DNA Repair

Bioactivity

Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is 115.8mM. Kobophenol A has protective effect against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.

Smiles

Oc1ccc(cc1)[C@H]1O[C@@H]([C@@H]([C@@H]1c1cc(O)cc(O)c1)c1cc(O)cc2O[C@@H]([C@H](c12)c1cc(O)cc2O[C@H]([C@@H](c12)c1cc(O)cc(O)c1)c1ccc(O)cc1)c1ccc(O)cc1)c1ccc(O)cc1