Isoangustone A
Product Specifications
CAS Number
129280-34-8
Target
Apoptosis, Autophagy, JNK, MAPK, PI3K
Related Pathways
Apoptosis, Autophagy, MAPK, PI3K/Akt/mTOR signaling
Purity
0.9889
Bioactivity
Isoangustone A is a natural product that inhibits PI3K, MKK4, and MKK7 through ATP competition, suppresses the expression of G1 phase regulatory proteins, inhibits the phosphorylation of Akt, GSK-3β, and JNK1/2, and inhibits the proliferation of human melanoma cells and tumour growth in xenograft mouse models.
Smiles
O=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=C(O)C(O)=C(C3)CC=C(C)C
Molecular Formula
C25H26O6
Molecular Weight
422.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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