Fortunellin
Product Specifications
CAS Number
20633-93-6
Target
AMPK, IκB/IKK
Related Pathways
Chromatin/Epigenetic, NF-κB, PI3K/Akt/mTOR signaling
Purity
0.9838
Bioactivity
Fortunellin is a flavonoid isolated from Fortunella margarita (kumquat) that alleviates histopathological heart injury while improving cardiac function by reducing inflammation and oxidative stress in fructose-induced metabolic disease models. Fortunellin decreases pro-inflammatory cytokines and suppresses phosphorylation of IKKα, IκBα, and NF-κB, while upregulating antioxidant defenses including SOD, CAT, HO-1, and activating AMPK/Nrf2 signaling, supporting the use of Fortunellin in research on diabetic cardiomyopathy and cardiometabolic disorders.
Smiles
O=C1C=2C(OC(=C1)C3=CC=C(OC)C=C3)=CC(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC2O
Molecular Formula
C28H32O14
Molecular Weight
592.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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