Excisanin A

PI3K/Akt/mTOR signaling, GPCR/G Protein, Stem Cells, NF-κB, MAPK, Apoptosis, Immunology/Inflammation, Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Proteases/Proteasome, DNA Damage/DNA Repair, Cytoskeletal Signaling

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP) .