Excisanin A
Product Specifications
CAS Number
78536-37-5
Target
MMP|||Integrin|||Prostaglandin Receptor|||FAK|||JNK|||GSK-3|||Akt|||Caspase|||PARP|||NF-?B|||Src|||PI3K|||Wnt/beta-catenin
Related Pathways
PI3K/Akt/mTOR signaling|||GPCR/G Protein|||Stem Cells|||NF-?B|||MAPK|||Apoptosis|||Immunology/Inflammation|||Angiogenesis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Proteases/Proteasome|||DNA Damage/DNA Repair|||Cytoskeletal Signaling
Bioactivity
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP) .
Smiles
CC1(C)CC[C@H](O)[C@@]2(C)[C@@H]3C[C@H](O)[C@@H]4[C@@H](O)[C@@]3([C@H](O)C[C@H]12)C(=O)C4=C
Molecular Formula
C20H30O5
Molecular Weight
350.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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