(R) -IDO/TDO-IN-1
(R) -IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties. (R) -IDO/TDO-IN-1 exhibits anti-tumor activity in MC38 xenograft model. (R) -IDO/TDO-IN-1 shows synergistic effect with anti-PD-1 monoclonal antibody (SHR-1210) [1].
Product Specifications
CAS Number
2033173-00-9
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/r-ido-tdo-in-1.html
Purity
98.04
Solubility
DMSO : 10 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
CN1N=CC(C2=CC=C(N3CCC([C@H](C4=C5C=CC=C4F)N6C5=CN=C6)CC3)C=C2)=C1
Molecular Formula
C25H24FN5
Molecular Weight
413.49
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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