Catalpalactone
Product Specifications
CAS Number
1585-68-8
Target
NF-κB, cAMP
Related Pathways
GPCR/G Protein, NF-κB
Bioactivity
Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities and enhance L-DOPA- induced cytotoxiciy in PC12 cells. Catalpalactone also exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA) -induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells.
Smiles
CC1(C)CC=C(C2OC(=O)c3ccccc23)C(=O)O1
Molecular Formula
C15H14O4
Molecular Weight
258.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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