DO-264
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.
Product Specifications
CAS Number
2301866-59-9
Product Name Alternative
GCA,GCA-2,(Rac)-GCA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DO-264.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
S=C(NC1=CC=CN=C1)NC2CCN(C3=NC=CC(OC4=CC=C(OC(F)(F)F)C=C4Cl)=C3Cl)CC2
Molecular Formula
C23H20Cl2F3N5O2S
Molecular Weight
558.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14 (12) :1099-1108.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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