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DO-264

DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.

Product Specifications

CAS Number

2301866-59-9

Product Name Alternative

GCA,GCA-2,(Rac)-GCA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DO-264.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

S=C(NC1=CC=CN=C1)NC2CCN(C3=NC=CC(OC4=CC=C(OC(F)(F)F)C=C4Cl)=C3Cl)CC2

Molecular Formula

C23H20Cl2F3N5O2S

Molecular Weight

558.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14 (12) :1099-1108.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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