DO-264
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.
Product Specifications
CAS Number
2301866-59-9
Product Name Alternative
GCA,GCA-2,(Rac)-GCA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DO-264.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
S=C(NC1=CC=CN=C1)NC2CCN(C3=NC=CC(OC4=CC=C(OC(F)(F)F)C=C4Cl)=C3Cl)CC2
Molecular Formula
C23H20Cl2F3N5O2S
Molecular Weight
558.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Ogasawara D, et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14 (12) :1099-1108.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY427570 100 µg
ALDH3A1 (NM_001135168) Human Over-expression Lysate
Sign In for Pricing
View Details 
