Capillarisin

NF-?B|||VEGFR|||Bcl-2 Family|||Reactive Oxygen Species|||IL Receptor|||NOS|||JNK|||MAPK|||COX|||STAT|||MMP|||Prostaglandin Receptor|||ERK|||TLR|||DNA/RNA Synthesis|||TNF

Neuroscience|||Proteases/Proteasome|||JAK/STAT signaling|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Tyrosine Kinase/Adaptors|||Immunology/Inflammation|||NF-?B|||Metabolism|||Apoptosis|||GPCR/G Protein|||MAPK|||Stem Cells|||Angiogenesis

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.