Capillarisin

NF-κB, VEGFR, Bcl-2 Family, Reactive Oxygen Species, IL Receptor, NOS, JNK, MAPK, COX, STAT, MMP, Prostaglandin Receptor, ERK, TLR, DNA/RNA Synthesis, TNF

Neuroscience, Proteases/Proteasome, JAK/STAT signaling, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Immunology/Inflammation, NF-κB, Metabolism, Apoptosis, GPCR/G Protein, MAPK, Stem Cells, Angiogenesis

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-ÎoB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.