(S) - (-) -Canadine
Product Specifications
CAS Number
5096-57-1
Target
ATPase|||Dopamine Receptor|||5-HT Receptor
Related Pathways
GPCR/G Protein|||Membrane transporter/Ion channel|||Neuroscience
Bioactivity
(S) - (-) -Canadine (tetrahydroberberine) is a naturally occurring isoquinoline alkaloid, acting as a D2 receptor antagonist and 5-HT1A receptor agonist, capable of blocking dopamine-stimulated adenylate cyclase activity. (S) - (-) -Canadine also enhances gastrointestinal motility, blocks K (ATP) channels in substantia nigra pars compacta (SNc) dopaminergic neurons, and exerts neuroprotective effects.
Smiles
O(C)C1=C2CN3[C@](C=4C(=CC5=C(C4)OCO5)CC3)(CC2=CC=C1OC)[H]
Molecular Formula
C20H21NO4
Molecular Weight
339.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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