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(S) - (-) -Canadine

Product Specifications

CAS Number

5096-57-1

Target

ATPase, Dopamine Receptor, 5-HT Receptor

Related Pathways

GPCR/G Protein, Membrane transporter/Ion channel, Neuroscience

Bioactivity

(S) - (-) -Canadine (tetrahydroberberine) is a naturally occurring isoquinoline alkaloid, acting as a D2 receptor antagonist and 5-HT1A receptor agonist, capable of blocking dopamine-stimulated adenylate cyclase activity. (S) - (-) -Canadine also enhances gastrointestinal motility, blocks K (ATP) channels in substantia nigra pars compacta (SNc) dopaminergic neurons, and exerts neuroprotective effects.

Smiles

O(C)C1=C2CN3[C@](C=4C(=CC5=C(C4)OCO5)CC3)(CC2=CC=C1OC)[H]

Molecular Formula

C20H21NO4

Molecular Weight

339.39

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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