Boehmenan
Product Specifications
CAS Number
57296-22-7
Target
MEK, EGFR, ERK, STAT, Caspase, PARP, Akt, Phosphatase, p53, Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, Apoptosis, Stem Cells, JAK/STAT signaling, Angiogenesis, Metabolism, MAPK, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair, Proteases/Proteasome
Bioactivity
(±) -Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC (50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.
Smiles
COc1cc(CCCOC(=O)\C=C\c2ccc(O)c(OC)c2)cc2[C@@H](COC(=O)\C=C\c3ccc(O)c(OC)c3)[C@@H](Oc12)c1ccc(O)c(OC)c1
Molecular Formula
C40H40O12
Molecular Weight
712.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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