Boehmenan
Product Specifications
Target
MEK|||EGFR|||ERK|||STAT|||Caspase|||PARP|||Akt|||Phosphatase|||p53|||Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling|||Chromatin/Epigenetic|||Apoptosis|||Stem Cells|||JAK/STAT signaling|||Angiogenesis|||Metabolism|||MAPK|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||DNA Damage/DNA Repair|||Proteases/Proteasome
Bioactivity
(±) -Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC (50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.
Smiles
COc1cc(CCCOC(=O)\C=C\c2ccc(O)c(OC)c2)cc2[C@@H](COC(=O)\C=C\c3ccc(O)c(OC)c3)[C@@H](Oc12)c1ccc(O)c(OC)c1
Molecular Formula
C40H40O12
Molecular Weight
712.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/302B8B01-C0AC-4948-88D6-ED7B6640BCAA/TN3525
CAS Number
57296-22-7
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