Para-Nitroblebbistatin

Para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology[1][2].

Product Specifications

CAS Number

[1621326-32-6]

UNSPSC

12352005

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/para-nitroblebbistatin.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 22 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1[C@]2(C(N(CC2)C3=CC=C(C=C3)[N+]([O-])=O)=NC4=C1C=C(C=C4)C)O

Molecular Formula

C18H15N3O4

Molecular Weight

337.33

References & Citations

[1]Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53 (31) :8211-5.|[2]Radnai L, et al. A simple and robust cell-based assay for the discovery of novel cytokinesis inhibitors. J Biol Methods. 2020 Sep 17;7 (3) :e136.