6-Acetonyldihydrochelerythrine
Product Specifications
CAS Number
22864-92-2
Target
PPAR, ERK, Akt, Bcl-2 Family, HIV Protease, p53
Related Pathways
Proteases/Proteasome, Metabolism, Microbiology/Virology, MAPK, Apoptosis, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair, Cytoskeletal Signaling
Bioactivity
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 cell lines, it displays potent cytotoxic activity in human HCT116 and SW620 colon carcinoma cells, to a higher extent than 5-fluorouracil (5-FU), the cornerstone chemotherapeutic agent in colon cancer.
Smiles
COc1ccc2-c3ccc4cc5OCOc5cc4c3N(C)[C@@H](CC(C)=O)c2c1OC
Molecular Formula
C24H23NO5
Molecular Weight
405.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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