4beta-Hydroxywithanolide E
Product Specifications
CAS Number
54334-04-2
Target
PPAR, COX, PARP, NF-κB, HSP
Related Pathways
Cytoskeletal Signaling, DNA Damage/DNA Repair, Neuroscience, Metabolism, Immunology/Inflammation, NF-κB, Chromatin/Epigenetic
Bioactivity
4beta-Hydroxywithanolide E (4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by modulating splicing factors and histone modifications.4bHWE is a useful natural anti-inflammatory compound to attenuate progression of diabetes and obesity, it decreases inflammatory responses by inhibiting the NF-ÎoB signaling in diabetic mouse adipose tissue, it also can improve impaired glucose tolerance.
Smiles
[H][C@@]12C[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3(O)CC[C@@]4(O)[C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]3(C)C(=O)C=C[C@H](O)[C@@]13O2 |c:37,t:26|
Molecular Formula
C28H38O8
Molecular Weight
502.604
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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