Britannilactone diacetate
Product Specifications
CAS Number
1286694-67-4
Target
ROS|||JAK|||MAPK|||JNK|||STAT|||IL Receptor|||Caspase|||PARP|||NO Synthase
Related Pathways
Tyrosine Kinase/Adaptors|||DNA Damage/DNA Repair|||Immunology/Inflammation|||JAK/STAT signaling|||Proteases/Proteasome|||Stem Cells|||Chromatin/Epigenetic|||Apoptosis|||Angiogenesis|||MAPK
Bioactivity
1,6-O, O-Diacetylbritannilactone (OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase C?-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.
Smiles
C[C@@H](CCCOC(C)=O)C1=C(C)C[C@H]2OC(=O)C(=C)[C@H]2[C@@H]1OC(C)=O
Molecular Formula
C19H26O6
Molecular Weight
350.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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