Tanshinone IIB
Product Specifications
CAS Number
17397-93-2
Target
Bcl-2 Family|||Apoptosis|||Caspase|||P-gp
Related Pathways
Apoptosis|||Proteases/Proteasome|||Neuroscience|||Membrane transporter/Ion channel
Bioactivity
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development.
Smiles
Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21
Molecular Formula
C19H18O4
Molecular Weight
310.349
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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