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Tanshinone IIB

Product Specifications

CAS Number

17397-93-2

Target

Bcl-2 Family|||Apoptosis|||Caspase|||P-gp

Related Pathways

Apoptosis|||Proteases/Proteasome|||Neuroscience|||Membrane transporter/Ion channel

Bioactivity

Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development.

Smiles

Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21

Molecular Formula

C19H18O4

Molecular Weight

310.349

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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