Scutebarbatine A
Product Specifications
CAS Number
176520-13-1
Target
Bcl-2 Family, Caspase, Apoptosis
Related Pathways
Proteases/Proteasome, Apoptosis
Bioactivity
Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 μM, respectively.
Smiles
[H][C@]12CCC=C(C)[C@]1(C)[C@@H](OC(=O)c1cccnc1)[C@H](OC(=O)c1cccnc1)[C@](C)(O)[C@]2(C)\C=C\C1=CC(=O)OC1
Molecular Formula
C32H34N2O7
Molecular Weight
558.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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