Pimaric acid
Product Specifications
CAS Number
127-27-5
Target
MMP, p38 MAPK, NF-κB, Apoptosis
Related Pathways
Proteases/Proteasome, NF-κB, Apoptosis, MAPK
Purity
0.8
Bioactivity
Pimaric acid is a naturally occurring resin acid identified in species such as Aralia cordata and various pine trees. Pimaric acid exerts anticancer effects through induction of endoplasmic reticulum stress, activation of caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in ovarian cancer cells. Additionally, pimaric acid suppresses mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs), supporting its role in cancer and vascular research.
Smiles
[H][C@]12CC[C@@](C)(C=C)C=C1CC[C@@]1([H])[C@@](C)(CCC[C@]21C)C(O)=O
Molecular Formula
C20H30O2
Molecular Weight
302.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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