Lucidenic acid B
Product Specifications
CAS Number
95311-95-8
Target
Apoptosis, Caspase
Related Pathways
Proteases/Proteasome, Apoptosis
Purity
0.98
Bioactivity
Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mitochondrial mediation. Lucidenic acid B inhibits PMA-induced invasion of human hepatocellular carcinoma cells by inactivating the MAPK/ERK signaling pathway and decreasing the binding activity of NF-kappaB and AP-1. Lucidenic acid B had no effect on cell cycle and necrotic cells.
Smiles
C[C@]12C3=C([C@]4(C)[C@@](C[C@@H]3O)(C(C)(C)C(=O)CC4)[H])C(=O)[C@@H](O)[C@]1(C)[C@@]([C@@H](CCC(O)=O)C)(CC2=O)[H]
Molecular Formula
C27H38O7
Molecular Weight
474.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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