Isosilybin A
Product Specifications
CAS Number
142796-21-2
Target
NF-κB, Apoptosis, p38 MAPK, Androgen Receptor, ABC Transporter, ERK, PPAR, Tyrosinase
Related Pathways
NF-κB, Endocrinology/Hormones, DNA Damage/DNA Repair, Membrane transporter/Ion channel, MAPK, Apoptosis, Metabolism, Proteases/Proteasome
Purity
0.9988
Bioactivity
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
Smiles
COc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
Molecular Formula
C25H22O10
Molecular Weight
482.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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