SGD-9501-TFA

GD-9501-TFA is an auristatin S-based ADC linker with effective off-target toxicity characteristics, which can be used for the preparation of antibody-drug conjugates (ADCs) [1].

Product Specifications

UNSPSC

12352203

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sgd-9501-tfa.html

Smiles

C[N+]([C@@H](CO)C(N[C@@H](C(C)C)C(N([C@@H]([C@H](CC)C)[C@@H](CC(N1[C@H]([C@@H]([C@H](C(N[C@@H](CC2=CC=CC=C2)CO)=O)C)OC)CCC1)=O)OC)C)=O)=O)(C)CC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3.FC(F)(F)C([O-])=O

Molecular Formula

C68H104F3N11O16

Molecular Weight

1388.61

References & Citations

[1]Payne K, et al. Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 2: Synthesis of the Payload, Linker, and Drug Linker[J]. Organic Process Research & Development, 2024.