SGD-9501-TFA
GD-9501-TFA is an auristatin S-based ADC linker with effective off-target toxicity characteristics, which can be used for the preparation of antibody-drug conjugates (ADCs) [1].
Product Specifications
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sgd-9501-tfa.html
Smiles
C[N+]([C@@H](CO)C(N[C@@H](C(C)C)C(N([C@@H]([C@H](CC)C)[C@@H](CC(N1[C@H]([C@@H]([C@H](C(N[C@@H](CC2=CC=CC=C2)CO)=O)C)OC)CCC1)=O)OC)C)=O)=O)(C)CC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)C=C3.FC(F)(F)C([O-])=O
Molecular Formula
C68H104F3N11O16
Molecular Weight
1388.61
References & Citations
[1]Payne K, et al. Process Development for the First GMP Synthesis of SGD-9501-TFA, Part 2: Synthesis of the Payload, Linker, and Drug Linker[J]. Organic Process Research & Development, 2024.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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