Gliotoxin
Product Specifications
CAS Number
67-99-2
Target
Wnt/beta-catenin, Antibacterial, Antibiotic, Antifection, Antifungal, COX, NF-κB, Apoptosis, PKA
Related Pathways
Stem Cells, Microbiology/Virology, Immunology/Inflammation, NF-κB, Neuroscience, Apoptosis, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Bioactivity
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.
Smiles
CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
Molecular Formula
C13H14N2O4S2
Molecular Weight
326.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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