Eriocalyxin B

Immunology/Inflammation|||GPCR/G Protein|||PI3K/Akt/mTOR signaling|||NF-?B|||Cell Cycle/Checkpoint|||Metabolism|||JAK/STAT signaling|||Stem Cells|||Autophagy|||Apoptosis|||Cytoskeletal Signaling|||DNA Damage/DNA Repair

Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells.