Bacopaside X

Bacopaside X is a triterpenoid saponin isolated from Bacopa monniera that exhibits strong antifungal and anticancer activities by actively suppressing pathogenic fungal growth and tumor progression, demonstrated through inhibition of Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus at MIC values of 50 µg/ml, along with significantly decreasing proliferation in cancer cell lines MDA-MB-231, SHG44, HCT8, A549, and PC3M with IC50 values of 14.3, 15.9, 9.8, 9.7, and 10.1 µM respectively. Bacopaside X additionally reduces tumor growth by 84.13% in an S180 sarcoma mouse allograft model when administered at a dose of 50 µmol/kg, indicating substantial therapeutic potential.

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