Alphitolic acid
Product Specifications
CAS Number
19533-92-7
Target
Akt, NF-κB, Apoptosis, Autophagy, TNF
Related Pathways
PI3K/Akt/mTOR signaling, NF-κB, Cytoskeletal Signaling, Autophagy, Apoptosis
Bioactivity
Alphitolic acid, a terpenoid from Potentilla freyniana Bornm, is a selective 3-hydroxy-3-methylglutamic acid coenzyme-A synthase 2 (HMGCS2) inhibitor with anti-inflammatory and anticancer activity that inhibits T cell proliferation in a concentration-dependent manner. Alphitolic acid induces apoptosis and autophagy.
Smiles
C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)[C@H](O)C5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]
Molecular Formula
C30H48O4
Molecular Weight
472.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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