Ingenol mebutate
Product Specifications
CAS Number
75567-37-2
Target
PKC, HIV Protease, gp120/CD4
Related Pathways
Immunology/Inflammation, Chromatin/Epigenetic, Proteases/Proteasome, Cytoskeletal Signaling, Microbiology/Virology
Purity
0.9976
Bioactivity
Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory and antitumor activity.
Smiles
C\C=C(\C)C(=O)O[C@H]1C(C)=C[C@@]23[C@H](C)C[C@@H]4[C@H]([C@H](C=C(CO)[C@@H](O)[C@]12O)C3=O)C4(C)C
Molecular Formula
C25H34O6
Molecular Weight
430.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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