Groenlandicine
Product Specifications
CAS Number
38691-95-1
Target
ROS, Apoptosis, Beta-Secretase, Cholinesterase (ChE), Topoisomerase
Related Pathways
Immunology/Inflammation, Apoptosis, DNA Damage/DNA Repair, Neuroscience
Purity
0.9977
Bioactivity
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR) . Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage; Groenlandicine may be a promising anti-Alzheimer's disease agent due to its potent inhibitory activity of both ChEs and beta-amyloids formation, as well as marked ONOO (-) scavenging and good ROS inhibitory capacities.
Smiles
O(C)C=1C=C2C=3[N+](=CC4=C(C3)C=CC5=C4OCO5)CCC2=CC1O
Molecular Formula
C19H16NO4
Molecular Weight
322.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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