Lupanine
Product Specifications
CAS Number
550-90-3
Target
AChR, Potassium Channel, Beta Amyloid
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Bioactivity
Lupanine ((+) -Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
Smiles
O=C1N2[C@@]([C@]3(C[C@@](C2)([C@]4(N(C3)CCCC4)[H])[H])[H])(CCC1)[H]
Molecular Formula
C15H24N2O
Molecular Weight
248.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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