Dehydroglyasperin D

DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint|||Endocrinology/Hormones|||GPCR/G Protein|||Metabolism|||Neuroscience|||Immunology/Inflammation|||Cytoskeletal Signaling|||Stem Cells|||MAPK

Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS (+), and singlet oxygen radicals.