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Dendrobium phenol

Product Specifications

CAS Number

67884-30-4

Target

Glucosidase, Wnt/beta-catenin

Related Pathways

Stem Cells, Cytoskeletal Signaling, Metabolism

Purity

0.9968

Bioactivity

Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol also shows α-glucosidase inhibitory activity.

Smiles

COc1cc(O)cc(CCc2ccc(OC)c(O)c2)c1

Molecular Formula

C16H18O4

Molecular Weight

274.31

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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