Dendrobium phenol
Product Specifications
CAS Number
67884-30-4
Target
Glucosidase|||Wnt/beta-catenin
Related Pathways
Stem Cells|||Cytoskeletal Signaling|||Metabolism
Purity
0.9968
Bioactivity
Gigantol is a novel inhibitor of the Wnt/?-catenin pathway. It inhibits Wnt/?-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic ?-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-?B signaling pathway.Gigantol also shows ?-glucosidase inhibitory activity.
Smiles
COc1cc(O)cc(CCc2ccc(OC)c(O)c2)c1
Molecular Formula
C16H18O4
Molecular Weight
274.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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