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NCT-58

Product Specifications

CAS Number

2411429-33-7

Target

Apoptosis, HSP

Related Pathways

Apoptosis, Cytoskeletal Signaling, Metabolism

Purity

0.996

Bioactivity

NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR) . NCT-58 elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.

Smiles

COc1cc(NC(=O)c2ccc3OC(C)(C)C=Cc3c2OC)ccc1OCCC1CCCCN1

Molecular Formula

C27H34N2O5

Molecular Weight

466.57

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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