NCT-58
Product Specifications
CAS Number
2411429-33-7
Target
Apoptosis|||HSP
Related Pathways
Apoptosis|||Cytoskeletal Signaling|||Metabolism
Purity
0.996
Bioactivity
NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR) . NCT-58 elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.
Smiles
COc1cc(NC(=O)c2ccc3OC(C)(C)C=Cc3c2OC)ccc1OCCC1CCCCN1
Molecular Formula
C27H34N2O5
Molecular Weight
466.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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