HQ461
Product Specifications
CAS Number
1226443-41-9
Target
Molecular Glues, CDK
Related Pathways
PROTAC, Cell Cycle/Checkpoint
Purity
0.9811
Bioactivity
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction, triggering cyclin K degradation, decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Smiles
Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
Molecular Formula
C15H15N5OS2
Molecular Weight
345.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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