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HQ461

Product Specifications

CAS Number

1226443-41-9

Target

Molecular Glues, CDK

Related Pathways

PROTAC, Cell Cycle/Checkpoint

Purity

0.9811

Bioactivity

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction, triggering cyclin K degradation, decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

Smiles

Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1

Molecular Formula

C15H15N5OS2

Molecular Weight

345.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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