JAK3-IN-11
Product Specifications
CAS Number
2412734-00-8
Target
JAK, Others
Related Pathways
Chromatin/Epigenetic, Stem Cells, Tyrosine Kinase/Adaptors, Others, Angiogenesis, JAK/STAT signaling
Bioactivity
JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently binds to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T-cell proliferation which is a promising tool for studying autoimmune diseases [1].
Smiles
N(C=1N=C(C=CN1)C2=CC=C(NC(C=C)=O)C=C2)C3=CC=C(C=C3)N4CCOCC4
Molecular Formula
C23H23N5O2
Molecular Weight
401.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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