JAK-IN-14
Product Specifications
CAS Number
1973485-06-1
Target
JAK
Related Pathways
Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling
Purity
0.9827
Bioactivity
JAK-IN-14 (compound 16) is a specific JAK1 inhibitor with IC50<5 μM. It prevents JAK1 phosphorylation by binding to the active site of JAK1, and is more than 8-fold selective for JAK1 over JAK2/JAK3, and can be used in immune, inflammation and cancer research.
Smiles
N#CCC=1C=CC(=C(F)C1)C2=CC=CC3=NC(=CN32)NC(=O)C4CC4
Molecular Formula
C19H15FN4O
Molecular Weight
334.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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